منابع مشابه
Relief from Contact Inhibition
The viral transformation of normal into tumorigenic cells is a system under active investigation . The fact that transformation is accompanied by loss of contact-inhibition has focused attention on other situations in which confluent cells can be caused to resume movement and cell division . One such system is the serum-stimulated relief of contact-inhibition in cultured fibroblasts (1, 2, 3) ....
متن کاملContact inhibition against senescence
Cellular senescence is a form of irreversible growth arrest historically associated with the exhaustion of replicative potential of in vitro cultured cells. Senescence can be triggered by many stimuli, including telomere attrition, DNA damage, oxidative stress, activation of oncogenes, and inactivation of tumor suppressor genes, and plays important roles in tumor suppression, organism aging, ti...
متن کاملFormation of Polyribosomes during Recovery from Contact Inhibition of Replication
Previous studies (3) of colony formation of 3T3, a cell line with the property of contact inhibition of replication, demonstrated a coincidence of cell contact and cessation of DNA synthesis and replication . Also, plating efficiency tests (3, 6) from monolayer cultures of 3T3 consistently have been in the range of 20%-30% for exponentially growing cells as well as cells in the state of contact...
متن کاملForcing contact inhibition of locomotion
Contact inhibition of locomotion drives a variety of biological phenomenon, from cell dispersion to collective cell migration and cancer invasion. New imaging techniques have allowed contact inhibition of locomotion to be visualised in vivo for the first time, helping to elucidate some of the molecules and forces involved in this phenomenon.
متن کاملRelief from IL-1
On page 1407, Decker and colleagues trick HIV into exposing itself. This trick revealed that a majority of infected individuals have broadly cross-reactive neutralizing antibodies against HIV in their circulation. Antibodies that neutralize diverse strains of HIV have been difficult to find, despite decades of searching. Several gp120-specific neutralizing anti-bodies have been cloned. Some of ...
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ژورنال
عنوان ژورنال: Journal of Cell Biology
سال: 1972
ISSN: 1540-8140,0021-9525
DOI: 10.1083/jcb.53.1.231